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Reference Details
Goffredo Filho, G. S. and Faerstein, E. (2010), "Temporary limitations in daily routine activities: association with arterial pressure and antihypertensive therapy", Arq Bras Cardiol, 94, 4: 472-6.

Abstract:
BACKGROUND: Arterial hypertension has a crucial role in the occurrence of severe clinical events, but there are controversies regarding the impact of the arterial pressure levels or anti-hypertensive medication on the routine activities of individuals. OBJECTIVE: To verify whether the increase in arterial pressure levels or anti-hypertensive medications determine a temporary incapacity for routine activities. METHODS: Analysis of sectional data of 2,953 participants, from 1999-2001, of a cohort of university employees in Rio de Janeiro (Pro-Saude Study). The occurrence and duration of the incapacity on the 14 days before data collection were assessed according to the measured level of arterial pressure, as continuous variable and with the stratification of the participants in four groups, combining the information regarding the arterial pressure (< or >or= 140/90 mmHg) and the reported use of anti-hypertensive medications. A multinomial logistic regression was carried out, with multiple adjustments for sex, age, ethnicity, per capita household income and report of comorbidities. RESULTS: The adjusted odds ratio for the association between the use of anti-hypertensive medication and incapacity for 8 to 14 days was 2.08 (95% CI: 1.25-3.48), and 0.92 (95%CI: 0.84-1.01) for the association between a 10 mmHg increase in systolic pressure and incapacity for up to 7 days. CONCLUSION: Temporary incapacity for 8 to 14 days associated to anti-hypertensive medications might be related to its adverse effects. Among other reasons, the suggestive inverse association between the systolic pressure and incapacity for up to 7 days can be related to the phenomenon of hypoalgesia, sometimes described by hypertensive individuals.

Keywords:
*Absenteeism *Activities of Daily Living Adult Aged Antihypertensive Agents/*adverse effects/therapeutic use Blood Pressure/*physiology Female Humans Hypertension/complications/*drug therapy/physiopathology Logistic Models Male Middle Aged Odds Ratio Time Factors Young Adult

Notes:
Goffredo Filho, Gilberto Senechal de Faerstein, Eduardo English Abstract Research Support, Non-U.S. Gov't Brazil Arquivos brasileiros de cardiologia Arq Bras Cardiol. 2010 Apr;94(4):472-6. Epub 2010 Mar 26.

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